Description

3α,17,21-Tris(Trimethylsiloxy)-5β-Pregnan-20-One o-Methyl Oxime is a high-purity, advanced pharmaceutical intermediate characterized by its specific steroidal structure with protective trimethylsilyl (TMS) groups. This compound is critical for researchers and manufacturers requiring precise chemical building blocks for the synthesis of complex steroid derivatives and active pharmaceutical ingredients (APIs). It is primarily utilized in the pharmaceutical and biotechnology sectors for process development, analytical reference standards, and the production of specialized therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development and manufacturing of steroid-based active pharmaceutical ingredients (APIs).
• Research & Development: Used in academic and industrial R&D laboratories for studying steroid chemistry, metabolic pathways, and receptor interactions.
• Process Chemistry: Employed in scale-up and optimization of synthetic routes for complex organic molecules in pilot plants and manufacturing facilities.
• Analytical Standard: Serves as a high-purity reference standard for quality control (QC) and analytical method development using HPLC, GC-MS, or NMR.
• Biochemical Research: Utilized in the study of enzyme inhibitors, hormone analogs, and other biologically active steroid compounds.
• Custom Synthesis: A starting material for the contract synthesis of specialized, non-commercial steroid derivatives for client-specific applications.

Basic Information

Product Name	3α,17,21-Tris(Trimethylsiloxy)-5β-Pregnan-20-One o-Methyl Oxime
CAS No.	56196-43-1
Molecular Formula	C30H57NO4Si3
Molecular Weight	580.03 g/mol
Synonyms	5β-Pregnan-20-one, 3,17,21-tris[(trimethylsilyl)oxy]-, O-methyloxime; 3α,17α,21-Tris-O-(trimethylsilyl)-5β-pregnan-20-one O-methyloxime; 3,17,21-Tris-O-trimethylsilyl-5β-pregnan-20-one methyloxime; Tris(trimethylsiloxy)pregnanone methyloxime; TMS-derivative of 5β-pregnan-20-one methyloxime
EINECS	Contact for details

Quality Control

Our 3α,17,21-Tris(Trimethylsiloxy)-5β-Pregnan-20-One o-Methyl Oxime is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical R&D and intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccant packs or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.