Description

{(1R,3R,5S)-3,5-Dihydroxy-2-[(E)-(3S)-3-Hydroxyoct-1-Enyl]Cyclopentyl}Acetic Acid is a high-purity, stereochemically defined prostaglandin intermediate of significant commercial and research interest. This compound is critical for the synthesis of advanced pharmaceutical agents, particularly in the development of prostaglandin analogues used in ophthalmology and other therapeutic areas. It is essential for R&D laboratories, process development chemists, and manufacturers in the fine chemical and active pharmaceutical ingredient (API) sectors who require a reliable, high-quality building block for complex synthesis.

Application

• Key Intermediate in Prostaglandin Synthesis: Serves as a crucial chiral precursor for the production of prostaglandin F2α analogues and related compounds.
• Pharmaceutical R&D: Used in research and development of new therapeutic agents targeting intraocular pressure, inflammation, and other physiological pathways.
• Active Pharmaceutical Ingredient (API) Manufacturing: Employed in the commercial-scale synthesis of prostaglandin-based APIs for ophthalmic solutions and other formulations.
• Process Chemistry & Scale-Up: Provides a defined starting point for process optimization and scale-up activities in fine chemical production.
• Biochemical Research: Utilized as a standard or probe in studies investigating prostaglandin receptors and signaling pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	{(1R,3R,5S)-3,5-Dihydroxy-2-[(E)-(3S)-3-Hydroxyoct-1-Enyl]Cyclopentyl}Acetic Acid
CAS No.	56188-04-6
Molecular Formula	C₁₅H₂₆O₅
Molecular Weight	286.36 g/mol
Synonyms	(+)-Fluprostenol Intermediate; (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic Acid (related isomer); 15(S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic Acid derivative; Prostaglandin F2α synthon; Travoprost Intermediate; Latanoprost related compound; (3aS,4R,5R,6aS)-5-[(1E,3S)-3-Hydroxyoct-1-en-1-yl]hexahydro-2H-cyclopenta[b]furan-2,4(3H)-dione derivative; 9,11,15-Trihydroxyprostadienoic Acid.
EINECS	Contact for details

Quality Control

Our {(1R,3R,5S)-3,5-Dihydroxy-2-[(E)-(3S)-3-Hydroxyoct-1-Enyl]Cyclopentyl}Acetic Acid is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and specific tests are provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This material is easily oxidized and moisture-sensitive; prolonged exposure to air should be avoided. Keep container tightly sealed in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5% Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.