Description

17,21-Dihydroxy-20-Oxo-5β-Pregnan-3α-Yl β-D-Glucopyranosiduronic Acid is a high-purity steroid glucuronide conjugate, a key intermediate and reference standard in advanced pharmaceutical research and development. This compound is critical for analytical method development, metabolite identification, and pharmacokinetic studies due to its role in steroid metabolism. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) focused on endocrinology, drug metabolism, and the synthesis of complex bioactive molecules.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of steroid metabolites in complex biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in the study of phase II metabolism pathways, specifically glucuronidation, to understand drug clearance and metabolite profiling.
• Biochemical Research: A vital tool for investigating steroid hormone pathways, enzyme activity (e.g., UDP-glucuronosyltransferases), and endocrine system function.
• Analytical Method Development: Employed to validate and calibrate analytical techniques such as HPLC, LC-MS, and GC-MS for sensitive and accurate detection of steroid conjugates.
• Impurity Profiling: Acts as a known impurity or metabolite standard in the quality control of steroid-based Active Pharmaceutical Ingredients (APIs).
• Clinical Diagnostics: Potential use in the development of diagnostic assays for measuring specific steroid hormone metabolites.

Basic Information

Product Name	17,21-Dihydroxy-20-Oxo-5β-Pregnan-3α-Yl β-D-Glucopyranosiduronic Acid
CAS No.	56162-40-4
Molecular Formula	C27H42O10
Molecular Weight	526.62 g/mol
Synonyms	5β-Pregnane-3α,17,21-triol-20-one 3-glucuronide; Tetrahydrocortisone Glucuronide; THE Glucuronide; 3α,17,21-Trihydroxy-5β-pregnan-20-one 3-Glucuronide; 5β-Pregnan-3α-ol-11,20-dione 21-Glucuronide (related); Steroid D-ring Glucuronide; Cortolone Glucuronide; Urocortisone Glucuronide
EINECS	Contact for details

Quality Control

Every batch of 17,21-Dihydroxy-20-Oxo-5β-Pregnan-3α-Yl β-D-Glucopyranosiduronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency, meeting the rigorous demands of research and development. A detailed Certificate of Analysis (COA) including results from HPLC, NMR, and MS is supplied with each shipment to guarantee compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.