Description

Norfluoxetine is a key pharmaceutical intermediate and metabolite of the widely used antidepressant fluoxetine. This compound is of significant importance for research and development in neuropharmacology and analytical chemistry. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for drug metabolism studies, impurity profiling, and the synthesis of reference standards.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and research of selective serotonin reuptake inhibitors (SSRIs).
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in pharmacokinetic studies.
• Metabolite Studies: Essential for investigating the metabolic pathways, bioavailability, and safety profile of fluoxetine.
• Impurity Profiling: Serves as a known impurity standard to ensure the purity and quality of fluoxetine active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in in-vitro and in-vivo studies to understand serotonin transporter (SERT) inhibition mechanisms.
• Forensic Toxicology: Used as an analytical standard in forensic labs for the detection and quantification of fluoxetine and its metabolites.

Basic Information

Product Name	Norfluoxetine
CAS No.	56161-73-0
Molecular Formula	C16H16F3NO
Molecular Weight	295.30 g/mol
Synonyms	(±)-Norfluoxetine; N-Desmethylfluoxetine; (RS)-Norfluoxetine; 3-Phenyl-3-[4-(trifluoromethyl)phenoxy]propylamine; Benzenepropanamine, γ-[4-(trifluoromethyl)phenoxy]-N-methyl-; LY248686 (Norfluoxetine); Fluoxetine Metabolite
EINECS	Contact for details

Quality Control

Our Norfluoxetine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.