Description

3-Bromo-2-Chlorobenzotrifluoride is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic positioning of bromine and chlorine substituents on a trifluoromethylated benzene ring, enabling selective functionalization and the construction of complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate in the development of active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic motifs for bioactivity or further derivatization.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the benzotrifluoride core contributes to favorable physicochemical properties.
• Material Science: Serves as a building block for liquid crystals, organic light-emitting diodes (OLEDs), and other advanced electronic materials due to its stable aromatic structure and halogen handles.
• Cross-Coupling Reactions: The bromine atom is an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Negishi couplings, enabling carbon-carbon bond formation.
• Functional Group Transformation: The chlorine substituent can be utilized for nucleophilic aromatic substitution or reduced, providing a handle for introducing diverse functional groups.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry R&D, facilitating the exploration of new chemical entities and scalable synthetic routes.

Basic Information

Product Name	3-Bromo-2-Chlorobenzotrifluoride
CAS No.	56131-47-6
Molecular Formula	C7H3BrClF3
Molecular Weight	259.45 g/mol
Synonyms	2-Chloro-3-bromobenzotrifluoride; 1-Bromo-2-chloro-3-(trifluoromethyl)benzene; 3-Bromo-2-chloro-α,α,α-trifluorotoluene; Benzene, 1-bromo-2-chloro-3-(trifluoromethyl)-; 2-Chloro-α,α,α-trifluoro-3-bromotoluene; 3-Bromo-2-chloro-(trifluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Chlorobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing identity, assay, and impurity profiles to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.