Description

2,4-Dioxo-1,2,3,4-Tetrahydro-Quinazoline-6-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative of a quinazoline-dione core, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a versatile electrophilic reagent for introducing the sulfonamide or sulfonate functional group under mild conditions, enabling the construction of complex molecules with precision. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in kinase inhibitor and anticancer agent research.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the quinazoline scaffold imparts specific biological activity.
• Material Science: Serves as a monomer or cross-linking agent in the synthesis of specialty polymers and functional materials.
• Bioconjugation & Probe Development: Utilized in biochemical research for labeling proteins, peptides, and other biomolecules due to its reactivity with amines.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic & R&D: Employed in university and institutional laboratories for methodological studies and exploring new chemical reactions.

Basic Information

Product Name	2,4-Dioxo-1,2,3,4-Tetrahydro-Quinazoline-6-Sulfonyl Chloride
CAS No.	56044-12-3
Molecular Formula	C8H5ClN2O4S
Molecular Weight	260.65 g/mol
Synonyms	6-Quinazolinesulfonyl chloride, 1,2,3,4-tetrahydro-2,4-dioxo-; Quinazoline-2,4(1H,3H)-dione-6-sulfonyl chloride; 2,4(1H,3H)-Quinazolinedione-6-sulfonyl chloride; 1,2,3,4-Tetrahydro-2,4-dioxoquinazoline-6-sulfonyl chloride; 6-Sulfonylchloride-2,4-quinazolinedione; TDQSC; CAS 56044-12-3
EINECS	Contact for details

Quality Control

Our 2,4-Dioxo-1,2,3,4-Tetrahydro-Quinazoline-6-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee traceability, consistency, and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.