Description

(-)-Bicuculline Methiodide CAS NO 55950-07-7 is a potent and selective antagonist of the GABAA receptor, widely used as a critical research tool in neuroscience and pharmacology. Its primary value lies in its ability to block inhibitory neurotransmission, making it indispensable for studying synaptic function, neuronal excitability, and the mechanisms of convulsants. This high-purity compound is essential for researchers and developers in pharmaceutical R&D, academic institutions, and biotechnology companies focused on neurological disorders, anesthetics, and receptor characterization.

Application

• Neuroscience Research: Fundamental tool for investigating GABAergic inhibition, synaptic plasticity, and neuronal network behavior in vitro and in vivo.
• Pharmacological Studies: Used to characterize and validate GABAA receptor subtypes, aiding in the development of receptor-specific drugs.
• Convulsant Mechanism Analysis: Employed to induce and study seizure models, helping to understand epilepsy and test potential anticonvulsant therapies.
• Ion Channel Research: Critical for patch-clamp and electrophysiology experiments to measure chloride currents and receptor kinetics.
• Biochemical Assays: Used in competitive binding assays and high-throughput screening (HTS) platforms for drug discovery targeting the GABAA receptor.
• Academic & Educational Use: A standard reagent in university laboratories for teaching advanced neuropharmacology and cellular signaling concepts.

Basic Information

Product Name	(-)-Bicuculline Methiodide
CAS No.	55950-07-7
Molecular Formula	C21H20NO6•CH3I
Molecular Weight	509.29 g/mol
Synonyms	(-)-Bicuculline Methiodide; Bicuculline Methiodide; (R)-(-)-Bicuculline Methiodide; NSC 224994; 1(S),9(R)-Bicuculline Methiodide; (1S,9R)-Bicuculline Methiodide; GABAA Receptor Antagonist (Bicuculline Methiodide); Bicuculline Methodide
EINECS	Contact for details

Quality Control

Our (-)-Bicuculline Methiodide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Solubility	Soluble in DMSO, Methanol; Slightly soluble in Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.