Description

5-Bromothiophenesulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative used as a key synthetic intermediate in advanced organic chemistry. Its primary value lies in its ability to act as a versatile electrophile for introducing the 5-bromothiophene-2-sulfonyl moiety, enabling the construction of complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in the development of enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the thiophene ring contributes to biological activity.
• Material Science Research: Serves as a precursor for functional polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing sulfonyl group.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and labeling reagents for proteomics and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for fine chemical and custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	5-Bromothiophenesulfonyl Chloride
CAS No.	55854-46-1
Molecular Formula	C4H2BrClO2S2
Molecular Weight	261.55 g/mol
Synonyms	5-Bromothiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 5-bromo-; 5-Bromo-2-thiophenesulfonyl chloride; 5-Bromothienyl-2-sulfonyl chloride; 5-Bromo-2-thienylsulfonyl chloride; 5-Bromothiophene-2-sulphonyl chloride; 2-Bromo-5-thiophenesulfonyl chloride (incorrect but common misnomer)
EINECS	Contact for details

Quality Control

Our 5-Bromothiophenesulfonyl Chloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.