Description

5-Methyl-2-Thiophenesulfonyl Chloride is a high-purity organosulfur building block and versatile sulfonylation reagent essential for advanced chemical synthesis. Its value lies in enabling the precise introduction of the 5-methylthiophene-2-sulfonyl moiety, a key structural feature in the development of novel active compounds. This intermediate is critically needed by research and development teams in the pharmaceutical, agrochemical, and material science industries for creating new molecules with targeted properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the thiophene sulfonyl group can enhance biological activity.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic electronic materials.
• Chemical Biology Probes: Employed to synthesize activity-based probes and affinity labels for studying biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs and fine chemical suppliers producing bespoke compounds for client R&D.

Basic Information

Item	Details
Product Name	5-Methyl-2-Thiophenesulfonyl Chloride
CAS No.	55854-45-0
Molecular Formula	C5H5ClO2S2
Molecular Weight	196.68 g/mol
Synonyms	5-Methylthiophene-2-sulfonyl chloride; 2-Thiophenesulfonyl chloride, 5-methyl-; 5-Methyl-2-thienylsulfonyl chloride; 5-Methylthienyl-2-sulfonyl chloride; 5-Methyl-2-thiophenesulphonyl chloride; 2-Sulfonylchloride-5-methylthiophene; 5-Methyl-2-thiophenesulfonic acid chloride
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-Thiophenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.