Description

4-Formylbenzal Fluoride, Alpha,α-Difluoro-p-Tolualdehyde is a versatile fluorinated aromatic aldehyde building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a formyl group and a difluoromethylidene moiety, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to introduce fluorine atoms and aldehyde functionality to enhance metabolic stability, bioavailability, and binding affinity in active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where the difluoro group improves lipophilicity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to alter thermal, chemical, and surface properties.
• Cross-coupling Reactions: The aldehyde group acts as a handle for further functionalization via reactions like Suzuki-Miyaura or Sonogashira coupling.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and organofluorine compounds.

Basic Information

Product Name	4-Formylbenzal Fluoride, Alpha,α-Difluoro-p-Tolualdehyde
CAS No.	55805-29-3
Molecular Formula	C8H4F2O
Molecular Weight	154.11 g/mol
Synonyms	4-(Difluoromethyl)benzaldehyde; α,α-Difluoro-p-tolualdehyde; p-(Difluoromethyl)benzaldehyde; 4-Formylbenzal Fluoride; 4-(Difluoromethyl)benzenecarboxaldehyde; Benzaldehyde, 4-(difluoromethyl)-; 1-(Difluoromethyl)-4-formylbenzene; p-Formylbenzal Fluoride
EINECS	Contact for details

Quality Control

Our production of 4-Formylbenzal Fluoride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including GC, HPLC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.