Description

1-(1,1-Difluoroethyl)-4-Fluorobenzene is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique difluoroethyl substituent, which introduces significant electronic and steric effects to modify molecular properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries to create novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of new drug candidates, particularly for introducing fluorine atoms to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine moiety improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting applications.
• Polymer Modification: Employed to incorporate fluorine-containing side chains into specialty polymers, improving their chemical resistance and surface properties.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) for constructing complex biaryl structures.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new fluorination methodologies and reaction mechanisms.

Basic Information

Product Name	1-(1,1-Difluoroethyl)-4-Fluorobenzene
CAS No.	55805-03-3
Molecular Formula	C8H7F3
Molecular Weight	160.14 g/mol
Synonyms	4-Fluoro-α,α-difluoroethylbenzene; 1-(4-Fluorophenyl)-1,1-difluoroethane; p-Fluoro-α,α-difluoroethylbenzene; (4-Fluorophenyl)difluoroethane; 1,1-Difluoro-1-(4-fluorophenyl)ethane; Difluoro(4-fluorophenyl)ethane; Benzene, 1-(1,1-difluoroethyl)-4-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 1-(1,1-Difluoroethyl)-4-Fluorobenzene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from strong acids and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.