Description

2-Fluoro-5-Hydroxypyridine is a versatile fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a fluorine atom and a hydroxyl group on the pyridine ring, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to introduce fluorine into target molecules to modulate their bioavailability, metabolic stability, and binding affinity.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the fluorine atom enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in metal-catalyzed cross-coupling reactions and other catalytic processes.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials.
• Fluorine Chemistry Research: A standard substrate for studying fluorination reactions and the effects of fluorine substitution on aromatic systems.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	2-Fluoro-5-Hydroxypyridine
CAS No.	55758-32-2
Molecular Formula	C5H4FNO
Molecular Weight	113.09 g/mol
Synonyms	5-Hydroxy-2-fluoropyridine; 2-Fluoro-5-pyridinol; 2-Fluoropyridin-5-ol; 5-Fluoropyridin-2-ol (tautomer); 2-Fluoro-5-hydroxypyridine; 5-Fluoro-2-hydroxypyridine; 2-F-5-OH-Pyridine; 55758-32-2
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-Hydroxypyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for fine chemical intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.