Description

Iodoacetic Acid (2-13C) is a stable isotope-labeled derivative of iodoacetic acid, where the carbon atom at the 2-position is enriched with the carbon-13 isotope. This compound is a critical reagent for advanced biochemical research, enabling precise metabolic pathway tracing and protein function studies through mass spectrometry and NMR spectroscopy. It is essential for researchers and manufacturers in the fields of pharmaceutical development, proteomics, and metabolic research who require high-purity, isotopically labeled compounds for accurate analytical results.

Application

• Biochemical Research: As an alkylating agent for selective modification of cysteine residues in proteins and enzymes.
• Metabolic Pathway Analysis: Used as a 13C-labeled tracer to study glycolysis and other central carbon metabolic fluxes.
• Proteomics & Mass Spectrometry: Serves as a stable isotope-coded affinity tag (ICAT) reagent for quantitative proteomic analysis.
• Pharmaceutical Development: Employed in the synthesis and metabolic studies of novel drug candidates and biomarkers.
• Enzyme Inhibition Studies: Acts as a potent inhibitor of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in mechanistic studies.
• Academic Research: A key tool in university and institutional labs for investigating protein structure-function relationships.

Basic Information

Product Name	Iodoacetic Acid (2-13C)
CAS No.	55757-50-1
Molecular Formula	C13CH2ICOOH
Molecular Weight	186.95 g/mol (for 13C1)
Synonyms	2-Iodoacetic-2-13C Acid; (2-13C)Iodoacetic Acid; Monoiodoacetic Acid-2-13C; IAA-13C; Iodo[2-13C]acetic Acid; Carboxy-13C-methyl Iodide; Isotope Labeled Iodoacetate
EINECS	Contact for details

Quality Control

Our Iodoacetic Acid (2-13C) is manufactured under strict quality control protocols to ensure high isotopic and chemical purity suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment, chemical purity, and impurity profile. We adhere to cGMP principles for research chemicals, ensuring traceability and consistency for critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive. Keep the container tightly sealed in a desiccated environment to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98%
Isotopic Enrichment (13C)	≥ 99 atom %
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.