Description

(-)-Butaclamol Hcl CAS NO 55528-08-0 is a high-purity, enantiomerically pure chemical compound belonging to the class of butyrophenone derivatives. This compound is of significant value as a potent and selective dopamine receptor antagonist, making it a critical reference standard and research tool in neuropharmacology. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and analytical service providers engaged in neuroscience, receptor binding studies, and the development of central nervous system (CNS) therapeutics.

Application

• Pharmacological Research: Used as a selective D1 and D2 dopamine receptor antagonist in receptor binding assays and functional studies to investigate dopaminergic pathways.
• Neuroscience Studies: Serves as a key reference compound in academic and industrial research focused on understanding schizophrenia, Parkinson's disease, and other CNS disorders.
• Pharmaceutical Development: Acts as a chemical standard in the synthesis and analytical method development for novel antipsychotic and neuroleptic drug candidates.
• Analytical Reference Standard: Employed in high-performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) for method validation, purity assessment, and quantification.
• Biochemical Assays: Utilized in vitro to study signal transduction mechanisms and the biochemical effects of dopamine receptor blockade.

Basic Information

Item	Details
Product Name	(-)-Butaclamol Hydrochloride
CAS No.	55528-08-0
Molecular Formula	C25H31NO.HCl
Molecular Weight	398.0 g/mol (free base: 361.5 g/mol)
Synonyms	(-)-Butaclamol HCl; (3aS,4R,4aR,5aS,6R,10bS,12aS)-4a,5,5a,6,7,8,9,10,10b,11,12,12a-Dodecahydro-3a,10b-dihydroxy-4-propyl-4H,6H-[1,3]dioxolo[4,5-g]pyrano[3',4':4,5]furo[2,3-h]isoquinolin-4-ium chloride; Dexbutaclamol Hydrochloride; AY-23,028; NSC 339024; Butaclamol Hydrochloride (-)-isomer
EINECS	Contact for details

Quality Control

Our (-)-Butaclamol HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure identity, potency, and purity meet the stringent requirements for pharmacological research. A detailed Certificate of Analysis (COA) providing batch-specific results for assay, related substances, residual solvents, and chiral purity is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.