Description

5-Oxa-17-Phenyl-18,19,20-Trinor Prostaglandin F1 Alpha Methyl Ester is a synthetic prostaglandin analog, a key intermediate in advanced pharmaceutical research and development. This compound is valued for its structural modifications, which are critical for studying receptor selectivity and developing novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on ophthalmology, cardiovascular, and inflammatory disease research.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel prostaglandin-based drug candidates targeting intraocular pressure, pulmonary hypertension, and other conditions.
• Biochemical Research: Used as a reference standard and probe in pharmacological studies to investigate prostaglandin receptor (FP, EP) interactions and signaling pathways.
• Ophthalmology Drug Development: Serves as a precursor in the research and development of next-generation glaucoma treatments, such as prostaglandin F2α analogs.
• Academic Research: Employed in university and institutional labs for fundamental studies in lipid mediator biology, synthetic organic chemistry, and medicinal chemistry.
• Process Chemistry & Scale-Up: Used by fine chemical suppliers for process optimization and the commercial-scale production of high-value active pharmaceutical ingredients (APIs).
• Analytical Standard: Provides a high-purity standard for method development and quality control (HPLC, GC-MS) in analytical laboratories.

Basic Information

Item	Details
Product Name	5-Oxa-17-Phenyl-18,19,20-Trinor Prostaglandin F1 Alpha Methyl Ester
CAS No.	55444-88-7
Molecular Formula	C₂₄H₃₄O₅
Molecular Weight	402.53 g/mol
Synonyms	5-Oxa-17-phenyl-18,19,20-trinor-PGF1α methyl ester; 17-Phenyl-18,19,20-trinor-5-oxa-prostaglandin F1α methyl ester; Methyl 5-oxa-17-phenyl-18,19,20-trinorprostaglandin F1α; 5-Oxa-17-phenyl-trinor-PGF1α-Me; Prostaglandin F1α analog methyl ester; PGF1α 5-oxa-17-phenyl trinor methyl ester; AL-8810 (related analog); FP receptor ligand intermediate
EINECS	Contact for details

Quality Control

Every batch of 5-Oxa-17-Phenyl-18,19,20-Trinor Prostaglandin F1 Alpha Methyl Ester is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity, meeting the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and full spectroscopic data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to protect against moisture. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.