Description

Trimethyl-β-Cyclodextrin is a chemically modified derivative of β-cyclodextrin, where three methyl groups are introduced to enhance its solubility and complexation properties. This modification is critical for improving the bioavailability, stability, and delivery of poorly soluble active ingredients in advanced formulations. It is an essential excipient and molecular encapsulation agent for research and industrial applications in the pharmaceutical, agrochemical, and food technology sectors. The product is supplied under stringent quality control to ensure batch-to-batch consistency for demanding processes.

Application

• Pharmaceutical Solubility Enhancement: Used to form inclusion complexes with hydrophobic drug molecules, significantly improving their aqueous solubility and dissolution rates for oral and injectable formulations.
• Flavor & Fragrance Stabilization: Acts as a molecular host to protect volatile or sensitive flavor compounds (e.g., citrus oils, spices) from oxidation, evaporation, or thermal degradation in food and cosmetic products.
• Agrochemical Delivery Systems: Employed to encapsulate pesticides or herbicides, enhancing their stability, reducing environmental volatility, and controlling release for improved efficacy.
• Analytical Chemistry & Chiral Separation: Serves as a chiral selector in capillary electrophoresis (CE) and high-performance liquid chromatography (HPLC) for the separation of enantiomers.
• Catalyst & Reaction Medium: Functions as a supramolecular catalyst or a green reaction medium in organic synthesis, facilitating reactions in aqueous environments.
• Personal Care Products: Used to stabilize active ingredients, control odor release, and enhance the performance of creams, lotions, and deodorants.

Basic Information

Product Name	Trimethyl-β-Cyclodextrin
CAS No.	55216-11-0
Molecular Formula	C63H112O35 (approximate, degree of substitution may vary)
Molecular Weight	~1429.5 g/mol (approximate)
Synonyms	Heptakis(2,6-di-O-methyl)-β-cyclodextrin; 2,6-Di-O-methyl-β-cyclodextrin; DIMEB; Methylated β-cyclodextrin; TM-β-CD; β-Cyclodextrin, methylated; Cyclodextrin, methyl-β-; Permethylated β-cyclodextrin
EINECS	Contact for details

Quality Control

Our Trimethyl-β-Cyclodextrin is manufactured under a quality management system and undergoes rigorous analytical testing to ensure it meets the high standards required for research and industrial use. Each batch is characterized for critical parameters including degree of substitution, purity, and residual solvents. A comprehensive Certificate of Analysis (COA) detailing specific test results is provided with every shipment. We can support compliance requirements for cGMP, REACH, and other relevant regulatory frameworks upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Degree of Substitution (DS)	Contact for details
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.