Description

S-3'-Deoxyadenosylhomocysteine is a specialized biochemical compound, a structural analog of S-adenosylhomocysteine (SAH) where the 3'-hydroxyl group of the ribose moiety is absent. This modification makes it a valuable tool compound and a potent inhibitor of S-adenosylhomocysteine hydrolase (SAHH), a key enzyme in the methylation cycle. It is essential for researchers and manufacturers in the life sciences sector requiring precise biochemical modulation. The compound is primarily utilized in pharmaceutical research, enzymology studies, and as a reference standard in analytical chemistry.

Application

• Biochemical Research: As a potent and specific inhibitor of S-adenosylhomocysteine hydrolase (SAHH) for studying cellular methylation pathways and epigenetic regulation.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the discovery and development of antiviral and anticancer therapeutics targeting methylation processes.
• Enzymology Studies: Used to investigate the kinetics and mechanism of methyltransferase enzymes in vitro.
• Diagnostic Reagent Manufacturing: Employed in the production of diagnostic kits and assays that measure methyltransferase activity or SAHH function.
• Academic Research: A critical tool for universities and research institutes exploring nucleotide metabolism, virology (particularly for certain RNA viruses), and signal transduction.
• Reference Standard: Used as a high-purity calibrant in analytical methods such as HPLC and LC-MS for quality control of related pharmaceutical compounds.

Basic Information

Product Name	S-3'-Deoxyadenosylhomocysteine
CAS No.	55197-15-4
Molecular Formula	C14H20N6O4S
Molecular Weight	368.42 g/mol
Synonyms	S-3'-Deoxyadenosyl-L-homocysteine; 3'-Deoxy-S-adenosylhomocysteine; 3'-dAdoHcy; 3'-Deoxy-SAH; 3'-Deoxy-S-adenosyl-L-homocysteine; Adenosyl-3'-deoxyhomocysteine; SAH Hydrolase Inhibitor (3'-deoxy); L-Homocysteine, S-[3-deoxy-5'-(adenin-9-yl)-β-D-ribofuranosyl]-
EINECS	Contact for details

Quality Control

Our S-3'-Deoxyadenosylhomocysteine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For custom purity grades or specific impurity profiles, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.