Description

1-(Trifluoroacetyl)-2-Piperidinecarboxylic Acid Butyl Ester is a high-purity fluorinated piperidine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its value lies in the trifluoroacetyl group, which introduces unique electronic and steric properties essential for developing novel compounds with enhanced metabolic stability and bioavailability. This product is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active pharmaceutical ingredients (APIs), complex ligands, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex drug candidates, particularly those targeting the central nervous system (CNS) and requiring fluorinated motifs for improved pharmacokinetics.
• Agrochemical Research: Used in developing novel pesticides and herbicides, where the fluorine atoms can increase lipophilicity and biological activity.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics: Incorporated into peptide analogs to enhance stability against enzymatic degradation, useful in medicinal chemistry.
• Fluorine Chemistry Research: An important reagent for academic and industrial research exploring the effects of fluorine substitution in organic molecules.
• Fine Chemical Production: Employed in the multi-step synthesis of specialty chemicals and high-value fluorinated compounds.

Basic Information

Product Name	1-(Trifluoroacetyl)-2-Piperidinecarboxylic Acid Butyl Ester
CAS No.	54965-28-5
Molecular Formula	C12H18F3NO3
Molecular Weight	281.27 g/mol
Synonyms	Butyl 1-(Trifluoroacetyl)piperidine-2-carboxylate; 2-Piperidinecarboxylic Acid, 1-(Trifluoroacetyl)-, Butyl Ester; 1-Trifluoroacetyl-2-piperidinecarboxylic Acid Butyl Ester; N-Trifluoroacetylpipecolinic Acid Butyl Ester; Butyl N-Trifluoroacetylpipecolate; Butyl 1-(2,2,2-Trifluoroacetyl)piperidine-2-carboxylate; N-Trifluoroacetyl-L-pipecolic Acid Butyl Ester (if applicable to stereoisomer); Contact for details on specific stereoisomers.
EINECS	Contact for details

Quality Control

Our 1-(Trifluoroacetyl)-2-Piperidinecarboxylic Acid Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.