Description

Jnk Inhibitor Ii, Negative Control is a well-characterized, cell-permeable compound specifically designed as a negative control for studies involving c-Jun N-terminal kinase (JNK) signaling pathways. This product is essential for validating the specificity of JNK inhibitors in biological assays, ensuring that observed effects are due to JNK inhibition and not off-target interactions. It is a critical research tool for scientists in pharmaceutical R&D, academic biochemistry, and molecular biology laboratories investigating cellular stress responses, apoptosis, and inflammatory diseases.

Application

• Specificity Control in JNK Pathway Research: Used as a critical negative control to confirm that experimental results from active JNK inhibitors are due to specific kinase inhibition.
• Cell-Based Assay Validation: Essential for validating high-throughput screening (HTS) assays and cell signaling studies targeting the MAPK pathway.
• Pharmacology and Toxicology Studies: Serves as a reference compound to distinguish between on-target and off-target effects of drug candidates.
• Academic and Institutional Research: Fundamental tool for basic research into mechanisms of apoptosis, neurodegeneration, and immune response regulation.
• Biomarker Discovery: Used in proteomics and genomics studies to help identify specific biomarkers associated with JNK activity.

Basic Information

Product Name	Jnk Inhibitor Ii, Negative Control
CAS No.	54642-23-8
Molecular Formula	C16H14N4O3S
Molecular Weight	342.37 g/mol
Synonyms	JNK Inhibitor II, Negative Control; Anthra[1,9-cd]pyrazol-6(2H)-one, 1,9-Dihydro-; SP 600125 Negative Control; JNK Inhibitor Negative Control; c-Jun N-terminal Kinase Inhibitor II Negative Control; (E)-3-(4-Methylsulfonylphenyl)-2-propenenitrile derivative (related structure); JNKi II Neg Ctrl
EINECS	Contact for details

Quality Control

Every batch of Jnk Inhibitor Ii, Negative Control is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with standards expected for high-purity biochemical reagents used in critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep under inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.