Description

Alprenolol Glucuronide is a key metabolite of the β-blocker drug alprenolol, formed via glucuronidation in the liver. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in preclinical and clinical studies.

Application

• Metabolite Reference Standard: Serves as a certified reference material (CRM) for the qualitative and quantitative analysis of alprenolol and its metabolites in biological matrices.
• Pharmacokinetic Studies: Used to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of alprenolol in drug development.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-UV methods for therapeutic drug monitoring (TDM) and toxicology studies.
• Enzyme Activity Assays: Employed in vitro to study the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes responsible for its formation.
• Drug-Drug Interaction Studies: Aids in research on potential interactions that may affect the metabolic pathway of alprenolol.
• Quality Control in Manufacturing: Acts as a system suitability standard in the quality control of alprenolol active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Alprenolol Glucuronide
CAS No.	54587-50-7
Molecular Formula	C22H33NO8
Molecular Weight	439.50 g/mol
Synonyms	1-(2-Allylphenoxy)-3-(isopropylamino)-2-propanol Glucuronide; Alprenolol β-D-Glucuronide; Alprenolol 1-O-β-D-Glucuronide; H 56/28 Glucuronide; (RS)-Alprenolol Glucuronide; (±)-Alprenolol Glucuronide; Alprenolol D-Glucuronide
EINECS	Contact for details

Quality Control

Our Alprenolol Glucuronide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC purity analysis, NMR and MS confirmation of structure, and determination of residual solvents and moisture content to ensure it meets the high standards required for research use. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccants and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.