Description

Ethacrynic Acid Mercapturate is a key metabolite of the loop diuretic ethacrynic acid, formed via conjugation with glutathione. This compound is of significant importance in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and nephrotoxicology. It serves as a critical reference standard and analytical tool for researchers and quality control laboratories in the pharmaceutical and life sciences industries.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of ethacrynic acid metabolites in biological matrices.
• Drug Metabolism Studies: Essential for investigating the metabolic pathways, bioavailability, and excretion profiles of ethacrynic acid in preclinical and clinical research.
• Toxicological Research: Employed in studies assessing the nephrotoxic potential and safety profile of ethacrynic acid and related compounds.
• Analytical Method Development: Serves as a critical standard for developing and validating high-performance liquid chromatography (HPLC), LC-MS/MS, and other analytical methods.
• Biomarker Research: Utilized in the development of assays to monitor drug exposure and metabolic response in patient samples.

Basic Information

Product Name	Ethacrynic Acid Mercapturate
CAS No.	54546-23-5
Molecular Formula	C16H19NO7S
Molecular Weight	369.39 g/mol
Synonyms	Ethacrynic Acid Cysteine Adduct; N-Acetyl-S-[2,3-dichloro-4-(2-methylenebutanoyl)phenoxy]-L-cysteine; Ethacrynic Acid Glutathione Conjugate Metabolite; EA-Mercapturate; EAM; Ethacrynic Acid Metabolite; 2-[2,3-Dichloro-4-(2-methylenebutanoyl)phenoxy]acetic acid mercapturate
EINECS	Contact for details

Quality Control

Our Ethacrynic Acid Mercapturate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and reference applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming batch-specific data.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.