Description

5α-Cholest-8(14)-Ene-3β,7,15-Triol is a high-purity, multi-hydroxylated sterol derivative of significant interest in advanced biochemical research and pharmaceutical development. This compound serves as a critical intermediate and reference standard for studying cholesterol biosynthesis pathways, metabolic regulation, and enzyme inhibition. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers focused on developing novel therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel sterol-based therapeutics targeting metabolic disorders.
• Biochemical Research: Used as a reference standard and probe molecule for investigating enzymes in the cholesterol biosynthesis pathway, such as oxidosqualene cyclase.
• Metabolic Pathway Studies: Essential for in vitro and in vivo studies to understand the regulation and inhibition of post-squalene cholesterol synthesis.
• Reference Standard: Serves as a high-purity analytical standard for HPLC, LC-MS, and NMR in quality control and method development laboratories.
• Enzyme Inhibition Assays: Employed in high-throughput screening (HTS) to identify and characterize potential inhibitors of specific sterol-modifying enzymes.
• Academic Research: Used in university and institutional labs for fundamental research into lipid biochemistry and cell signaling mechanisms.

Basic Information

Product Name	5α-Cholest-8(14)-Ene-3β,7,15-Triol
CAS No.	54411-51-7
Molecular Formula	C₂₇H₄₆O₃
Molecular Weight	418.66 g/mol
Synonyms	5α-Cholest-8(14)-ene-3β,7α,15α-triol; (3β,7α,15α)-5α-Cholest-8(14)-ene-3,7,15-triol; 3β,7α,15α-Trihydroxy-5α-cholest-8(14)-ene; 15α-Hydroxycholesterol derivative; 8(14)-Cholestene-3β,7α,15α-triol; 5α-Cholest-8(14)-ene-3β,7α,15α-triol
EINECS	Contact for details

Quality Control

Our 5α-Cholest-8(14)-Ene-3β,7,15-Triol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and IR for structural confirmation, and specific tests for residual solvents and moisture. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific research or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.