Description

Noscapine n-Oxide is a key pharmaceutical intermediate and metabolite of the natural alkaloid noscapine. This compound is of significant interest in research and development for its potential pharmacological activities and as a reference standard. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in drug discovery, metabolism studies, and analytical method development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel therapeutic agents and analogs.
• Metabolite Reference Standard: Essential for the identification and quantification of noscapine metabolites in pharmacokinetic and bioanalytical studies.
• Biochemical Research: Used in investigations of antitussive mechanisms, tubulin-binding activity, and other cellular pathways.
• Analytical Chemistry: Employed as a high-purity standard for HPLC, LC-MS, and other chromatographic methods to ensure accuracy and compliance.
• Quality Control & Assurance: Acts as a certified reference material (CRM) for the quality testing of noscapine-based APIs and finished dosage forms.

Basic Information

Product Name	Noscapine n-Oxide
CAS No.	54383-36-7
Molecular Formula	C22H23NO8
Molecular Weight	429.42 g/mol
Synonyms	Noscapine N-Oxide; Narcotine N-Oxide; 1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydroisoquinolin-2-ium-1-olate; (-)-Noscapine N-Oxide; α-Narcotine N-Oxide; L-α-Narcotine N-Oxide; Opianyl-N-oxide
EINECS	Contact for details

Quality Control

Our Noscapine n-Oxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.