Description

(Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,R)-4-Phenoxy-3-Hydroxy-1-Butenyl]Cyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester is a high-purity synthetic prostaglandin intermediate of significant pharmaceutical importance. This compound serves as a critical building block in the synthesis of advanced therapeutic agents, particularly those targeting ocular and cardiovascular systems. It is essential for research institutions, pharmaceutical R&D laboratories, and API manufacturers engaged in developing novel prostaglandin-based drugs.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A key chiral intermediate in the production of prostaglandin analogues like Latanoprost, Bimatoprost, and Travoprost.
• Ophthalmic Drug Development: Used in research and manufacturing of medications for glaucoma and ocular hypertension.
• Cardiovascular Research: Serves as a precursor for prostaglandins involved in vascular tone and platelet aggregation studies.
• Chemical Process Development: Employed in optimizing synthetic routes and scaling up production for prostaglandin derivatives.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• Academic & Contract Research: Supports investigative studies in medicinal chemistry and prostaglandin pharmacology.

Basic Information

Product Name	(Z)-7-[(1R)-3α,5α-Dihydroxy-2β-[(E,R)-4-Phenoxy-3-Hydroxy-1-Butenyl]Cyclopentan-1α-Yl]-5-Heptenoic Acid Methyl Ester
CAS No.	54348-08-2
Molecular Formula	C23H32O6
Molecular Weight	404.50 g/mol
Synonyms	Latanoprost Intermediate; Prostaglandin F2α Methyl Ester Derivative; (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-4-(Phenoxy)-3-hydroxy-1-buten-1-yl]cyclopentyl]-5-heptenoic Acid Methyl Ester; 15(R)-17-Phenyl-18,19,20-trinorprostaglandin F2α Methyl Ester; Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(3R)-3-hydroxy-4-phenoxy-1-butenyl]cyclopentyl]-5-heptenoate (related); Travoprost Key Intermediate; Bimatoprost Precursor; PhXA41 Methyl Ester
EINECS	Contact for details

Quality Control

Our production of this prostaglandin intermediate adheres to strict cGMP guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and IR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles against established specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or under refrigeration (2-8°C) for long-term stability. Due to its sensitivity to oxidation, the product should be stored under an inert atmosphere (e.g., nitrogen or argon) after opening. Keep the container in a dry, well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Optical Rotation	Contact for details
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.