Description

3-Fluoro-2-Nitropyridine is a versatile fluorinated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing nitro group and a fluorine atom, makes it a valuable precursor for creating complex molecules with tailored properties. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Building block for developing advanced herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and environmental stability.
• Material Science Research: Used in the creation of specialty polymers, liquid crystals, and electronic materials that require fluorinated aromatic components.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Nucleophilic Aromatic Substitution: The fluorine atom is readily displaced by various nucleophiles, enabling efficient introduction of diverse functional groups.
• Chemical Library Development: A valuable scaffold for medicinal chemistry and high-throughput screening to discover new bioactive compounds.

Basic Information

Product Name	3-Fluoro-2-Nitropyridine
CAS No.	54231-35-5
Molecular Formula	C5H3FN2O2
Molecular Weight	142.09 g/mol
Synonyms	2-Nitro-3-fluoropyridine; 3-Fluoro-2-nitropyridine; Pyridine, 3-fluoro-2-nitro-; 3-Fluoropyridine, 2-nitro-; 3-Fluoro-2-nitro-pyridine; 2-Nitro-3-fluoro-pyridine; 54231-35-5; 3-F-2-NO2-Py
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-Nitropyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to meet the stringent requirements of our global customer base in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere for long-term storage). Keep away from heat, sparks, and open flame. Isolate from incompatible materials such as strong reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.