Description

R(+)-IAA-94 is a potent and selective inhibitor of the volume-regulated anion channel (VRAC). This compound is a critical research tool for studying cellular volume regulation, apoptosis, and the role of anion transport in various physiological and pathological processes. It is essential for researchers in pharmacology, neurobiology, and oncology seeking to elucidate ion channel mechanisms. The product is supplied with the CAS number 54197-31-8.

Application

• Pharmacological Research: A key tool compound for investigating the function and inhibition of Volume-Regulated Anion Channels (VRAC/LRRC8) in vitro and in vivo.
• Neurobiology Studies: Used to study the role of anion channels in neuronal excitability, ischemic cell death (e.g., in stroke models), and glial cell function.
• Cancer Research: Employed to probe the contribution of VRAC to regulatory volume decrease (RVD) in cancer cells and its impact on cell proliferation and apoptosis.
• Cardiovascular Research: Applied in studies of cardiac arrhythmias and ischemic preconditioning where anion channel activity is implicated.
• Cell Physiology: Fundamental for experiments on cellular osmolarity, ion homeostasis, and membrane transport mechanisms.
• Drug Discovery: Serves as a reference standard and lead compound for developing novel therapeutics targeting anion channels for conditions like epilepsy, cancer, and ischemia.

Basic Information

Product Name	R(+)-IAA-94
CAS No.	54197-31-8
Molecular Formula	C15H12ClNO3S
Molecular Weight	321.78 g/mol
Synonyms	R-(+)-Indanyloxyacetic acid 94; (R)-(+)-[(6,7-Dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid; IAA-94; R-IAA-94; VRAC Inhibitor IAA-94; LRRC8 Channel Blocker; NSC 24112; (R)-6,7-Dichloro-2-cyclopentyl-5-indanyloxyacetic acid
EINECS	Contact for details

Quality Control

Every batch of R(+)-IAA-94 is manufactured and analyzed under strict quality management protocols to ensure high purity and batch-to-batch consistency for research applications. Identity, purity, and impurity profiles are verified using advanced analytical techniques including HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.