Description

Tranilast CAS NO 53902-17-3 is a synthetic anti-allergic and anti-fibrotic agent, recognized for its ability to inhibit the release of chemical mediators from mast cells and suppress transforming growth factor-beta (TGF-β) activity. This dual mechanism makes it a valuable compound for research and development in addressing inflammatory and fibrotic pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and manufacturers of active pharmaceutical ingredients (APIs) targeting conditions such as asthma, keloids, and other fibrotic disorders.

Application

• Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of finished dosage forms and novel drug candidates.
• Anti-fibrotic Research: Used in preclinical and clinical research to study its efficacy against tissue fibrosis, including pulmonary, renal, and cardiac fibrosis.
• Anti-allergic Agent Development: Employed in the development of therapeutics for allergic conditions such as asthma, allergic rhinitis, and atopic dermatitis.
• Keloid & Hypertrophic Scar Treatment: Investigated for topical or systemic applications to prevent and treat excessive scar formation.
• Ophthalmic Research: Studied for potential applications in treating ocular inflammatory and fibrotic diseases.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for HPLC, LC-MS, or NMR methods.

Basic Information

Product Name	Tranilast
CAS No.	53902-17-3
Molecular Formula	C18H17NO5
Molecular Weight	327.33 g/mol
Synonyms	N-(3,4-Dimethoxycinnamoyl)anthranilic acid; Rizaben; SB 252218; Tranilastum; Tranilast (USAN); N-(3,4-Dimethoxycinnamoyl)anthranilic Acid; 2-[[(2E)-3-(3,4-Dimethoxyphenyl)prop-2-enoyl]amino]benzoic acid
EINECS	258-904-7

Quality Control

Our Tranilast is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with detailed Certificates of Analysis (COA), which include results from HPLC, NMR, and residual solvent analysis. Specifications can meet various pharmacopeial or custom requirements for research and cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.