Description

Lodoxamide Ethyl is a synthetic organic compound belonging to the chromone carboxylic acid class, primarily recognized for its potent mast cell stabilizer properties. This high-purity active pharmaceutical ingredient (API) is critical for developing targeted ophthalmic solutions that manage allergic inflammatory responses. It is essential for pharmaceutical manufacturers and R&D facilities focused on advanced ocular therapeutics. The compound is supplied under stringent quality controls to ensure batch-to-batch consistency for formulation development and commercial production.

Application

• Primary Pharmaceutical Ingredient: As the active component in prescription ophthalmic solutions for the treatment of allergic conjunctivitis, vernal keratoconjunctivitis, and other mast cell-mediated ocular allergies.
• Drug Formulation R&D: Used in research and development of new topical drug delivery systems, including gels, suspensions, and novel nano-formulations.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research: Employed in pharmacological studies to investigate mast cell stabilization mechanisms and anti-allergic pathways.
• Veterinary Pharmaceuticals: Potential application in developing ophthalmic treatments for allergic eye conditions in animals.

Basic Information

Product Name	Lodoxamide Ethyl
CAS No.	53882-13-6
Molecular Formula	C17H14ClN2O8
Molecular Weight	409.76 g/mol
Synonyms	Lodoxamide Ethyl Ester; Lodoxamide Ethylate; 2,2'-(1,3-Dioxo-1,3-propanediyl)bis[N-(2,6-dichlorophenyl)glycine] Diethyl Ester; Lodoxamide; U-42585E; Alomide (brand name associated with the ophthalmic solution); Ethyl Lodoxamate; Contact for details on additional synonyms.
EINECS	Contact for details

Quality Control

Our Lodoxamide Ethyl is manufactured and tested to meet the exacting standards required for pharmaceutical active ingredients. Quality assurance protocols are designed to ensure identity, purity, strength, and composition. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including HPLC, IR, and NMR. Our quality system supports compliance with cGMP guidelines, and we can provide documentation to support regulatory filings (e.g., DMF).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.