Description

Monomethyl Phthalate o-β-D-Glucuronide is a specific glucuronide conjugate of a monomethyl phthalate derivative, serving as a crucial reference standard and metabolite in advanced biochemical research. This compound is essential for analytical method development and validation, particularly in studies involving xenobiotic metabolism and excretion pathways. It is primarily utilized by research institutions, pharmaceutical developers, and contract research organizations (CROs) engaged in pharmacokinetics, toxicology, and environmental biomonitoring.

Application

• Analytical Reference Standard: For the precise quantification and identification of phthalate metabolites in complex biological matrices using techniques like LC-MS/MS and HPLC.
• Metabolite Research: Critical for studying the Phase II conjugation (glucuronidation) pathways of phthalate esters in mammalian systems.
• Biomarker Development: Used in the development and calibration of assays for human biomonitoring to assess exposure to specific phthalates.
• Toxicological Studies: Serves as a definitive standard in research investigating the distribution, metabolism, and elimination (DME) of phthalate compounds.
• Pharmaceutical Impurity Profiling: Employed in method development for detecting and characterizing glucuronidated impurities or metabolites in drug substances.
• Quality Control: Acts as a system suitability standard in analytical laboratories to ensure the performance of chromatographic systems for conjugate analysis.

Basic Information

Product Name	Monomethyl Phthalate o-β-D-Glucuronide
CAS No.	53819-80-0
Molecular Formula	C16H18O10
Molecular Weight	370.31 g/mol
Synonyms	Monomethyl Phthalate Glucuronide; MMPG; o-Monomethyl Phthalate β-D-Glucuronide; Phthalic Acid Monomethyl Ester Glucuronide; 1-O-(Monomethyl Phthaloyl)-β-D-Glucopyranuronic Acid; (o-Carbomethoxyphenyl)-β-D-glucopyranosiduronic Acid; Glucuronic Acid Conjugate of Monomethyl Phthalate
EINECS	Contact for details

Quality Control

Every batch of Monomethyl Phthalate o-β-D-Glucuronide is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including chromatographic purity analysis and spectroscopic identification, to meet the exacting standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 95.0%
Water Content	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.