Description

Mevalonic-2-13C Lactone is a stable, isotopically labeled derivative of mevalonic acid, a key intermediate in the isoprenoid biosynthesis pathway. This compound is essential for advanced metabolic flux analysis and research into cholesterol biosynthesis, terpenoid production, and other critical biochemical pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors who require precise isotopic tracers for mass spectrometry-based studies.

Application

• Metabolic Pathway Tracing: Used as a 13C-labeled precursor in studies of the mevalonate pathway for cholesterol and isoprenoid biosynthesis.
• Pharmaceutical R&D: Critical for drug discovery and development targeting HMG-CoA reductase and related enzymes.
• Biochemical Research: Serves as a standard or reagent in enzymatic assays and metabolic flux analysis (MFA).
• Mass Spectrometry: Employed as an internal standard for the accurate quantification of mevalonic acid and its metabolites via LC-MS or GC-MS.
• Nutraceutical Studies: Applied in research on the biosynthesis of coenzyme Q10, carotenoids, and other isoprenoids.

Basic Information

Product Name	Mevalonic-2-13C Lactone
CAS No.	53771-22-5
Molecular Formula	C6H1013CO3
Molecular Weight	133.13 g/mol (for 13C-labeled form)
Synonyms	(R)-Mevalonic acid-2-13C lactone; 3-Hydroxy-3-methyl-5-valerolactone-2-13C; 5-(1-Hydroxy-1-methylethyl)dihydrofuran-2(3H)-one-2-13C; Mevalonolactone-2-13C; (R)-3-Hydroxy-3-methyl-5-oxotetrahydrofuran-2-13C; Dihydro-5-(2-hydroxyisopropyl)-2(3H)-furanone-2-13C; Isotopically labeled mevalonolactone
EINECS	Contact for details

Quality Control

Our Mevalonic-2-13C Lactone is produced under strict quality management systems to ensure high isotopic and chemical purity, critical for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and identity confirmation. We adhere to relevant standards for research-grade biochemicals, ensuring reliability and consistency for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C NMR)	≥ 99 atom % 13C
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.