Description

Cytochalasin J is a potent, cell-permeable fungal metabolite belonging to the cytochalasin family, known for its specific ability to disrupt actin microfilament polymerization. This compound is a critical research tool in cell biology for studying cytoskeletal dynamics, cell motility, and cytokinesis. It is primarily utilized by researchers and scientists in the fields of life sciences, pharmacology, and biotechnology for in vitro studies.

Application

• Cytoskeleton Research: A primary tool for inhibiting actin polymerization, enabling studies on cell shape, motility, and intracellular transport.
• Cell Division Studies: Used to investigate cytokinesis and the role of the actin contractile ring in cell division processes.
• Pharmacological Screening: Serves as a reference compound or biochemical probe in high-throughput screening for novel therapeutics targeting the cytoskeleton.
• Cancer Research: Employed to study metastasis and tumor cell invasion mechanisms that depend on actin remodeling.
• Neuroscience: Applied in research on growth cone dynamics and synaptic plasticity where actin filaments play a crucial role.
• Developmental Biology: Used to examine morphogenetic movements and cell fate determination during embryogenesis.

Basic Information

Product Name	Cytochalasin J
CAS No.	53760-20-6
Molecular Formula	C29H37NO5
Molecular Weight	479.61 g/mol
Synonyms	7-Dehydro-14,20-dihydroxy-16-methyl-10-phenyl[11]cytochalasa-6(12),13,21-triene-1,23-dione; NSC 339524; Cytochalasin J (from *Phomopsis* sp.); [11]Cytochalasa-6(12),13,21-triene-1,23-dione, 7-dehydro-14,20-dihydroxy-16-methyl-10-phenyl-
EINECS	Contact for details

Quality Control

Our Cytochalasin J is produced under stringent quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is easily oxidized and light-sensitive. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.