Description

Desacetylvinblastineamide is a specialized vinca alkaloid derivative, a key intermediate in the synthesis of complex pharmaceutical compounds. Its primary commercial value lies in its role as a crucial building block for developing potent anti-mitotic agents used in oncology research and drug development. This high-purity intermediate is essential for pharmaceutical manufacturers and advanced research institutions focused on creating next-generation chemotherapeutic treatments and studying microtubule dynamics.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of vinblastine, vincristine, and related semi-synthetic vinca alkaloid chemotherapeutic agents.
• Oncology Research: Used as a reference standard and active material in biochemical research targeting microtubule assembly and cancer cell proliferation studies.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a key starting material (KSM) or intermediate in the multi-step GMP production of approved anticancer drugs.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop novel analogs with improved efficacy or reduced toxicity profiles.
• Biochemical Reagent: Utilized in in vitro assays to study the mechanism of action of tubulin-binding agents and their effects on cell cycle arrest.

Basic Information

Product Name	Desacetylvinblastineamide
CAS No.	53643-48-4
Molecular Formula	C44H56N4O8
Molecular Weight	768.95 g/mol
Synonyms	Vindesine Sulfate Precursor; 23-Amino-4-deacetoxyvincaleukoblastine; Deacetylvinblastine Amide; 4-Deacetylvinblastine-23-amide; DAVA; NSC 245467; LY 099094; Vinblastine Amide
EINECS	Contact for details

Quality Control

Our Desacetylvinblastineamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH Q7 guidelines and can supply material that meets the specifications required for use as a pharmaceutical intermediate in GMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.