Description

(-)-Bicuculline Methochloride is a potent and selective competitive antagonist of the GABAA receptor, a key target in neuropharmacological research. This high-purity compound is essential for studying inhibitory neurotransmission, neuronal excitability, and the mechanisms underlying various neurological disorders. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic laboratories focused on neuroscience, anesthesiology, and anticonvulsant drug discovery.

Application

• Neuroscience Research: Fundamental tool for investigating GABAergic synaptic transmission, receptor subunit specificity, and neuronal network behavior in vitro and in vivo.
• Pharmacological Studies: Used to characterize new GABAA receptor modulators, anticonvulsants, and anesthetics by establishing a baseline of receptor blockade.
• Disease Model Development: Critical for inducing neuronal hyperexcitability in models of epilepsy, seizures, and anxiety disorders for therapeutic screening.
• Electrophysiology: Standard antagonist applied in patch-clamp and other electrophysiological recordings to isolate and study GABAA receptor-mediated currents.
• Biochemical Assays: Employed in receptor binding assays (e.g., competitive displacement of [3H]GABA) to determine ligand affinity and receptor density.
• Educational & Diagnostic Use: Serves as a reference standard in academic teaching and in the development of diagnostic tests for neurological conditions.

Basic Information

Product Name	(-)-Bicuculline Methochloride
CAS No.	53552-05-9
Molecular Formula	C21H21ClNO6 • CH3Cl
Molecular Weight	509.31 g/mol (for the methochloride salt)
Synonyms	(-)-Bicuculline Methochloride; (S)-(-)-Bicuculline Methochloride; Bicuculline Methochloride; Bicuculline Methodide (common misnomer); NSC 224994; GABAA Receptor Antagonist; 1(S),9(R)-Bicuculline Methochloride; (1S,9R)-6-[(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one methochloride
EINECS	Contact for details

Quality Control

Our (-)-Bicuculline Methochloride is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Each batch is supplied with a comprehensive Certificate of Analysis (COA) detailing results for assay, chiral purity, and specified impurities. We adhere to stringent in-house standards suitable for research and development applications, with the capability to support GMP-grade production for advanced preclinical studies upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider desiccant use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity ([α]D)	Specified range provided on COA
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual unknown ≤0.5%; Total ≤1.0%
Solubility	Soluble in DMSO, slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.