Description

2'-Hydroxymethylmethaqualone Glucuronide is a specific glucuronide metabolite of methaqualone, a compound of significant interest in analytical and forensic chemistry. Its primary value lies in its role as a critical reference standard for the accurate identification and quantification of methaqualone and its metabolites in complex biological matrices. This compound is essential for laboratories in the pharmaceutical research, forensic toxicology, and clinical diagnostics sectors, where precise metabolite profiling is required for method development, validation, and quality control.

Application

• Reference Standard for Analytical Methods: Used as a certified standard in HPLC, LC-MS/MS, and GC-MS for the detection of methaqualone metabolites.
• Forensic Toxicology: Critical for confirming the presence of methaqualone use in urine, blood, or hair samples in legal and workplace testing.
• Pharmacokinetic & Metabolism Studies: Employed in research to understand the metabolic pathways, clearance rates, and bioavailability of methaqualone.
• Clinical Laboratory Testing: Serves as a calibrator or control in diagnostic assays designed for drug monitoring and abuse screening.
• Pharmaceutical Impurity Profiling: Used to identify and quantify glucuronide conjugate impurities in drug substance analysis.
• Regulatory Compliance & Method Validation: Essential for laboratories to comply with guidelines from agencies like the FDA, SAMHSA, or WADA, ensuring test accuracy and reliability.

Basic Information

Product Name	2'-Hydroxymethylmethaqualone Glucuronide
CAS No.	53551-53-4
Molecular Formula	C25H26N2O9
Molecular Weight	498.48 g/mol
Synonyms	2'-Hydroxymethylmethaqualone β-D-Glucuronide; Methaqualone 2'-Hydroxymethyl Glucuronide; 3-[(2-Hydroxymethyl)-2-methyl-4-quinazolinyl]-2-methylphenyl β-D-Glucopyranosiduronic Acid; HMM-Gluc; Methaqualone Metabolite Glucuronide; Quinazolinone Glucuronide Metabolite
EINECS	Contact for details

Quality Control

Every batch of 2'-Hydroxymethylmethaqualone Glucuronide is manufactured and analyzed under strict quality systems. Our products undergo rigorous quality testing to ensure identity, purity, and stability, meeting the high standards required for analytical reference materials. Comprehensive Certificates of Analysis (COA) detailing batch-specific results from techniques such as NMR, HPLC, and MS are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.