Description

2,2-Dimethylpropane-1-Sulfonyl Chloride is a specialized sulfonyl chloride derivative, a key building block in organic synthesis. Its value lies in its role as a versatile reagent for introducing the neopentylsulfonyl group, which can impart steric bulk and metabolic stability to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A critical reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for creating sulfonamide and sulfonate ester functionalities.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the neopentylsulfonyl moiety enhances biological activity and environmental persistence.
• Polymer Chemistry: Serves as a monomer or modifying agent in the production of specialty polymers with specific sulfonyl group properties.
• Material Science: Employed in surface modification and the creation of advanced materials with tailored interfacial characteristics.
• Chemical Research: A valuable tool in medicinal chemistry for structure-activity relationship (SAR) studies and prodrug design.
• Peptide Modification: Used to selectively modify amino acid side chains, such as cysteine, in peptide and protein chemistry.

Basic Information

Product Name	2,2-Dimethylpropane-1-Sulfonyl Chloride
CAS No.	53333-76-9
Molecular Formula	C5H11ClO2S
Molecular Weight	170.66 g/mol
Synonyms	Neopentylsulfonyl chloride; 1-(Chlorosulfonyl)-2,2-dimethylpropane; 2,2-Dimethyl-1-propanesulfonyl chloride; Pivalylsulfonyl chloride; tert-Butylmethylsulfonyl chloride; NSC 163082; (2,2-Dimethylpropyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2,2-Dimethylpropane-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including assay by titration and identification by FT-IR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (Titration)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC/HPLC)	≤ 2.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.