Description

S-(3-Deazaadenosyl)Homocysteine is a stable analog of the key metabolic intermediate S-adenosylhomocysteine (SAH), specifically designed to resist enzymatic hydrolysis. This compound is a crucial biochemical tool for researchers investigating methylation pathways, epigenetic regulation, and enzyme kinetics, particularly for S-adenosylhomocysteine hydrolase (SAHH). It is primarily utilized in pharmaceutical R&D, academic biochemistry laboratories, and biotechnology companies focused on developing novel therapeutics targeting methylation-dependent processes.

Application

• Biochemical Research: Used as a stable inhibitor or substrate analog in studies of transmethylation reactions and S-adenosylhomocysteine hydrolase (SAHH) activity.
• Epigenetics & Drug Discovery: Serves as a key reference compound and tool for screening and developing inhibitors targeting DNA and protein methyltransferases for cancer and other diseases.
• Enzyme Mechanism Studies: Employed to elucidate the catalytic mechanism and binding affinity of methyltransferases due to its resistance to cleavage.
• Metabolic Pathway Analysis: Acts as a critical reagent in cellular and in vitro assays to modulate the SAM/SAH ratio and study its impact on cellular metabolism.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and other chromatographic methods for quantitative analysis in biological samples.

Basic Information

Product Name	S-(3-Deazaadenosyl)Homocysteine
CAS No.	53199-57-8
Molecular Formula	C14H20N6O4S
Molecular Weight	368.42 g/mol
Synonyms	3-Deaza-S-adenosylhomocysteine; 3-Deaza-SAH; 3-Deazaadenosylhomocysteine; S-(3-Deazaadenosyl)-L-homocysteine; 5'-S-(3-Deazaadenosyl)-L-homocysteine; 3-Deaza-S-adenosyl-L-homocysteine; 3-DZSAH; AdoHcy analog
EINECS	Contact for details

Quality Control

Our S-(3-Deazaadenosyl)Homocysteine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.