Description

Nisoxetine CAS NO 53179-07-0 is a selective norepinephrine reuptake inhibitor (NRI) of significant interest in pharmaceutical research and development. Its primary value lies in its utility as a key reference standard and a crucial intermediate in the synthesis of novel therapeutic agents targeting the central nervous system. This compound is essential for researchers and manufacturers in the pharmaceutical industry, particularly those focused on developing treatments for neurological and psychiatric conditions, as well as for analytical laboratories requiring high-purity chemical standards.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug testing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical building block in the multi-step synthesis of more complex drug candidates, particularly those acting on neurotransmitter systems.
• Neuroscience Research: Employed in preclinical studies to investigate the role of norepinephrine reuptake inhibition in various behavioral models and disease states.
• Biochemical Assay Development: Utilized as a tool compound to screen for and characterize the activity of other potential NRIs or related compounds.
• Metabolite Synthesis: Acts as a precursor for the synthesis of potential human or animal metabolites for toxicological and pharmacokinetic studies.

Basic Information

Product Name	Nisoxetine
CAS No.	53179-07-0
Molecular Formula	C17H21NO2
Molecular Weight	271.35 g/mol
Synonyms	LY-94,839; (R,S)-N-Methyl-3-(2-methylphenoxy)-3-phenylpropylamine; 3-((2-Methylphenoxy)methyl)-N-methyl-3-phenylpropylamine; (±)-Nisoxetine; 3-Phenyl-3-(o-tolyloxy)propylmethylamine; trans-(±)-Nisoxetine; LY 94839; NSC 339024
EINECS	Contact for details

Quality Control

Our Nisoxetine is manufactured under a strict quality management system to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by chromatographic techniques (HPLC). A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to guarantee product integrity and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.