Description

Phosgene-13C Solution is a stable isotope-labeled derivative of phosgene, where the central carbon atom is the carbon-13 (13C) isotope. This product is essential for advanced research and development, providing a critical tool for mechanistic studies, metabolic pathway tracing, and analytical method development using techniques like mass spectrometry and NMR. It is primarily utilized by pharmaceutical R&D laboratories, agrochemical innovators, and academic institutions focused on reaction mechanism elucidation and the synthesis of isotopically labeled compounds.

Application

• Isotopic Tracer Studies: Used as a 13C-labeled reagent to trace reaction pathways and mechanisms in organic synthesis.
• Pharmaceutical Intermediate Synthesis: A key building block for introducing the 13C-labeled carbonyl group into target molecules for drug discovery and development.
• Mass Spectrometry (MS) Internal Standards: Serves as a precursor for synthesizing labeled internal standards for precise quantitative analysis via LC-MS or GC-MS.
• Metabolic Research: Employed in studies investigating the metabolic fate of compounds that incorporate phosgene-derived functionalities.
• NMR Spectroscopy: Provides a distinct 13C NMR signal for structural analysis and reaction monitoring.
• Agrochemical Research: Used in the synthesis of isotopically labeled pesticides or herbicides for environmental and metabolic studies.

Basic Information

Product Name	Phosgene-13C Solution
CAS No.	53120-07-3
Molecular Formula	13CCl2O
Molecular Weight	99.93 g/mol (for 13C)
Synonyms	Carbon-13 Phosgene; Carbonyl-13C Chloride; [13C]-Phosgene; [13C]-Carbonyl Chloride; 13C-Labeled Phosgene; Carbonic Dichloride-13C; Phosgene-13C; Isotopic Phosgene
EINECS	Contact for details

Quality Control

Our Phosgene-13C Solution is produced and handled under stringent conditions to ensure isotopic and chemical purity. Each batch undergoes rigorous analytical testing, including isotopic enrichment analysis by NMR or MS, chemical purity assay, and solvent verification. A comprehensive Certificate of Analysis (COA) detailing isotopic purity, chemical assay, and relevant specifications is provided with every shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area, away from heat sources and incompatible materials such as strong bases, amines, and alcohols. Due to its nature as a strong acid/organic solvent and highly volatile compound, appropriate secondary containment and fume hood handling are mandatory. Specific temperature recommendations are provided on the product label and COA.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR / NMR)	Conforms to structure
Isotopic Purity (13C)	≥ 99 atom % 13C
Chemical Purity (Assay)	≥ 98.0% (by GC or titration)
Solvent	Toluene or as specified
Concentration	Typically 1.0M to 2.0M in solvent

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.