Description

Diethyl Malonate (1,2,3-13C3) is a stable isotope-labeled analog of diethyl malonate, where the carbon atoms at positions 1, 2, and 3 are enriched with the 13C isotope. This compound is an essential building block and internal standard for quantitative analysis in pharmaceutical research, metabolic studies, and advanced organic synthesis. It is primarily used by scientists and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry industries who require precise tracking of molecular pathways and accurate mass spectrometry measurements.

Application

• Internal Standard for Quantitative Mass Spectrometry (MS): Used as a reference standard in LC-MS and GC-MS for the accurate quantification of malonate derivatives and related metabolites in complex biological matrices.
• Pharmaceutical Intermediate Synthesis: Serves as a key 13C-labeled precursor in the synthesis of isotopically labeled active pharmaceutical ingredients (APIs) for drug metabolism and pharmacokinetics (DMPK) studies.
• Metabolic Pathway Tracing: Employed in biomedical and biochemical research to trace and elucidate metabolic fluxes and pathways using 13C NMR spectroscopy or mass spectrometry.
• Agrochemical Research: Utilized in the development and analysis of isotopically labeled pesticides or herbicides to study environmental fate, degradation, and residue analysis.
• Organic Synthesis Building Block: Acts as a labeled reagent in various name reactions, such as the Knoevenagel condensation, for introducing a 13C-labeled 1,3-dicarbonyl moiety into target molecules.
• Clinical Diagnostics: Potential use in the development of specialized diagnostic assays and kits that require isotopically labeled compounds for high precision.

Basic Information

Product Name	Diethyl Malonate (1,2,3-13C3)
CAS No.	53051-81-3
Molecular Formula	C13C3H14O4 or C7H14O4 (13C3)
Molecular Weight	163.15 g/mol (for 13C3 labeled form)
Synonyms	Diethyl Propanedioate-1,2,3-13C3; Diethyl Malonate-13C3; Malonic Acid Diethyl Ester-1,2,3-13C3; Diethyl 1,2,3-13C3-malonate; DEM-13C3; Ethyl Malonate-13C3; Propanedioic Acid, Diethyl Ester-1,2,3-13C3; Diethyl Methanedicarboxylate-13C3
EINECS	Contact for details

Quality Control

Our Diethyl Malonate (1,2,3-13C3) is manufactured under strict quality control protocols to ensure high isotopic and chemical purity, critical for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment, chemical purity, and solvent residue levels. We adhere to relevant industry standards for stable isotope-labeled compounds to guarantee reliable and reproducible performance in your research and development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Isotopic Enrichment (13C)	≥ 99 atom % (1,2,3-13C3)
Chemical Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.