Description

(5Z,13E,15S)-9-Oxo-15-(Trimethylsiloxy)Prosta-5,8(12),13-Trien-1-Oic Acid Trimethylsilyl Ester is a key synthetic intermediate and protected derivative of prostaglandin analogs. This compound is critically important for pharmaceutical research and development, particularly in the synthesis of prostaglandin-based therapeutics. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions engaged in the study of eicosanoid chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of prostaglandin analogs and related bioactive molecules.
• Drug Discovery Research: Used in medicinal chemistry programs to develop new therapeutic agents targeting inflammation, cardiovascular function, and ocular pressure.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in studies investigating the biological pathways and mechanisms of action of eicosanoids.
• Fine Chemical Synthesis: Utilized in multi-step organic syntheses requiring protected carboxylic acid and hydroxyl functionalities.
• Process Chemistry Development: Acts as a key intermediate in scaling up the production of prostaglandin-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	(5Z,13E,15S)-9-Oxo-15-(Trimethylsiloxy)Prosta-5,8(12),13-Trien-1-Oic Acid Trimethylsilyl Ester
CAS No.	53044-54-5
Molecular Formula	C₂₆H₄₆O₄Si₂
Molecular Weight	478.82 g/mol
Synonyms	9-Oxo-15-(trimethylsiloxy)prosta-5,8(12),13-trien-1-oic acid trimethylsilyl ester; 15-(Trimethylsiloxy)-9-oxoprosta-5,8(12),13-trien-1-oic acid TMS ester; Prostaglandin A1 bis(trimethylsilyl) ether; PGA1 bis-TMS ether; 15-TMS-PGA1-1-TMS; (5Z,13E)-(15S)-9-Oxo-11,15-bis(trimethylsiloxy)prosta-5,8(12),13-trien-1-oic acid; 9-Keto-PGA1 bis(trimethylsilyl) derivative
EINECS	Contact for details

Quality Control

Our (5Z,13E,15S)-9-Oxo-15-(Trimethylsiloxy)Prosta-5,8(12),13-Trien-1-Oic Acid Trimethylsilyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment to support your research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.