Description

(2E)-3-De[2-[Acetyl(Methyl)Amino]-1-Oxopropoxy]-2,3-Didehydro-22-Demethylmaytansine is a highly specialized synthetic derivative of the potent maytansinoid class, designed for advanced pharmaceutical research and development. This compound is critical for the development of Antibody-Drug Conjugates (ADCs), a cutting-edge class of targeted cancer therapeutics. It serves as a key cytotoxic payload, enabling researchers and pharmaceutical manufacturers to create highly potent and specific treatments for oncology applications. The compound's precise structure allows for controlled linkage to monoclonal antibodies, driving innovation in targeted drug delivery.

Application

• Antibody-Drug Conjugate (ADC) Payload: Primary application as the cytotoxic warhead in the development of targeted cancer therapies.
• Oncology Research: Used in preclinical and clinical research to study the efficacy and mechanisms of novel ADC constructs.
• Bioconjugation Chemistry: Serves as a model compound for developing and optimizing linker-payload technologies.
• Pharmaceutical Development: Critical intermediate in the synthesis and scale-up of investigational new drugs (INDs) and new drug applications (NDAs).
• Mechanistic Studies: Utilized in biochemical assays to understand tubulin inhibition and apoptosis induction in cancer cells.
• Process Chemistry: Employed in the development of robust and scalable synthetic routes for complex maytansinoid derivatives.

Basic Information

Product Name	(2E)-3-De[2-[Acetyl(Methyl)Amino]-1-Oxopropoxy]-2,3-Didehydro-22-Demethylmaytansine
CAS No.	52978-29-7
Molecular Formula	C35H46ClN3O9
Molecular Weight	688.21 g/mol
Synonyms	DM1; Mertansine; Maytansinoid DM1; N2-Deacetyl-N2-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; NSC-330507; (2E)-3-De[2-[Acetyl(Methyl)Amino]-1-Oxopropoxy]-2,3-Didehydro-22-Demethylmaytansine
EINECS	Contact for details

Quality Control

Our (2E)-3-De[2-[Acetyl(Methyl)Amino]-1-Oxopropoxy]-2,3-Didehydro-22-Demethylmaytansine is manufactured under strict quality systems suitable for pharmaceutical research. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Quality is assured through rigorous testing via HPLC, NMR, and MS, with specifications aligned with the needs of ADC development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.