Description

(2E)-3-De[2-[Acetyl(Methyl)Amino]-1-Oxopropoxy]-2,3-Didehydromaytansine is a highly specialized and potent maytansinoid derivative, a class of compounds renowned for their significant biological activity. This compound is of critical importance in advanced pharmaceutical research and development, particularly in the field of targeted cancer therapies. It serves as a key intermediate or payload in the synthesis of Antibody-Drug Conjugates (ADCs), which are designed to deliver cytotoxic agents directly to cancer cells, thereby minimizing systemic side effects. The demand for this high-purity compound is driven by leading pharmaceutical, biotechnology, and advanced contract research organizations globally.

Application

• Primary Payload for Antibody-Drug Conjugates (ADCs): As a potent cytotoxic agent, it is conjugated to monoclonal antibodies to create targeted cancer therapeutics.
• Advanced Oncology Research: Used in preclinical and clinical studies to investigate novel mechanisms of action and efficacy against various tumor types.
• Bioconjugation Chemistry Development: Serves as a model compound for developing and optimizing new linker technologies and conjugation methodologies.
• Pharmaceutical Intermediate Synthesis: Acts as a crucial building block in the multi-step synthesis of complex therapeutic molecules.
• Mechanistic Studies & Target Validation: Employed in biochemical assays to study tubulin inhibition and apoptosis pathways.

Basic Information

Product Name	(2E)-3-De[2-[Acetyl(Methyl)Amino]-1-Oxopropoxy]-2,3-Didehydromaytansine
CAS No.	52978-28-6
Molecular Formula	C35H46ClN3O9
Molecular Weight	688.21 g/mol
Synonyms	DM1; Mertansine; Maytansinoid DM1; N2′-Deacetyl-N2′-(3-mercapto-1-oxopropyl)-maytansine; Ansamitocin P-3 derivative; NSC-330507; (2E)-3-De[2-[Acetyl(Methyl)Amino]-1-Oxopropoxy]-2,3-Didehydro-Maytansine
EINECS	Contact for details

Quality Control

Every batch of (2E)-3-De[2-[Acetyl(Methyl)Amino]-1-Oxopropoxy]-2,3-Didehydromaytansine is manufactured and tested under strict quality systems to ensure it meets the exacting standards required for pharmaceutical development. Our quality control protocols are designed to support regulatory filings (e.g., IND, NDA) and include comprehensive analytical characterization. Certificates of Analysis (COA) are provided with each shipment, detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, controlled environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.