Description

H-Phe-Chloromethylketone Hcl is a specialized chloromethyl ketone derivative of phenylalanine, widely utilized as a key building block and protease inhibitor in biochemical research and pharmaceutical development. This compound is valued for its role in studying enzyme mechanisms and as a precursor in the synthesis of more complex bioactive molecules. It is primarily sought by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in proteomics and drug discovery programs.

Application

• Protease Inhibition Studies: Acts as an active site-directed irreversible inhibitor for serine and cysteine proteases, crucial for elucidating enzymatic pathways.
• Pharmaceutical Intermediate: Serves as a critical synthetic precursor in the development of novel therapeutic agents targeting specific proteases.
• Biochemical Research Reagent: Used in academic and industrial laboratories for protein characterization and enzyme kinetic analysis.
• Peptidomimetic Synthesis: Employed in the design and construction of peptide analogs and mimetics for drug candidate optimization.
• Apoptosis Research: Applied in cell biology studies to investigate caspase-mediated pathways and programmed cell death.

Basic Information

Product Name	H-Phe-Chloromethylketone Hcl
CAS No.	52735-71-4
Molecular Formula	C12H15Cl2NO2 • HCl
Molecular Weight	308.62 g/mol
Synonyms	L-Phenylalanine Chloromethyl Ketone Hydrochloride; Phenylalanine Chloromethyl Ketone HCl; Phe-CH2Cl HCl; (S)-2-Amino-3-phenyl-1-chloropropan-1-one Hydrochloride; TPCK Analog; Protease Inhibitor; ZPCK; N-[(Benzyloxy)carbonyl]-L-phenylalanyl chloromethane; Chymotrypsin Inhibitor
EINECS	Contact for details

Quality Control

Our H-Phe-Chloromethylketone Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. Certificates of Analysis (COA) detailing all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.