Description

n-Formyl-4-Iodo-L-Phenylalanine is a protected, iodinated derivative of the essential amino acid L-phenylalanine. This compound is a crucial chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in peptide chemistry, radiopharmaceutical development, and the synthesis of targeted therapeutic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel peptide-based drugs and targeted therapeutics.
• Radiopharmaceutical Development: Serves as a versatile intermediate for labeling with radioactive iodine isotopes (e.g., I-123, I-125, I-131) for diagnostic imaging and targeted radiotherapy.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected, side-chain modified amino acid to introduce iodine handles for further functionalization or conjugation.
• Chemical Biology Probes: Employed in the creation of affinity probes, enzyme inhibitors, and molecular tools for studying biological processes.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Sonogashira) due to the reactive aryl iodide moiety, enabling the construction of complex molecular architectures.
• Research & Development: Essential for academic and industrial R&D in medicinal chemistry and drug discovery programs.

Basic Information

Product Name	n-Formyl-4-Iodo-L-Phenylalanine
CAS No.	52721-77-4
Molecular Formula	C10H10INO3
Molecular Weight	319.10 g/mol
Synonyms	4-Iodo-N-formyl-L-phenylalanine; Fmoc-Phe(4-I)-OH (common precursor); N-Formyl-4-iodo-L-phenylalanine; (S)-2-Formylamino-3-(4-iodophenyl)propanoic acid; L-Phenylalanine, N-formyl-4-iodo-; 4-Iodo-L-phenylalanine N-formyl derivative; N-For-Phe(4-I)-OH
EINECS	Contact for details

Quality Control

Our n-Formyl-4-Iodo-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (L-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.