Description

Lincomycin B Hydrochloride is a semi-synthetic derivative of the lincosamide class of antibiotics, specifically the hydrochloride salt of Lincomycin B. This compound is valued for its potent antibacterial activity, particularly against Gram-positive bacteria and certain anaerobes, by inhibiting protein synthesis. It serves as a critical reference standard and active pharmaceutical ingredient (API) for research, quality control, and the development of antimicrobial agents. Key industries that utilize this product include pharmaceutical R&D, analytical laboratories, and fine chemical synthesis.

Application

• Pharmaceutical Reference Standard: Used for the identification, assay, and impurity profiling of lincomycin-based drug products in quality control laboratories.
• Antimicrobial Research: Serves as a key intermediate or active component in microbiological studies and the development of new antibiotic formulations.
• Veterinary Medicine: Employed in the research and production of antimicrobial treatments for livestock and companion animals.
• Biochemical Research: Utilized as a tool compound to study bacterial protein synthesis mechanisms and resistance patterns.
• Analytical Method Development: Acts as a calibrant for developing and validating HPLC, LC-MS, and other chromatographic methods.

Basic Information

Product Name	Lincomycin B Hydrochloride
CAS No.	11021-35-5
Molecular Formula	C18H34N2O6S • HCl
Molecular Weight	461.00 g/mol (as hydrochloride)
Synonyms	Lincomycin B HCl; (2S,4R)-N-[(1S,2S,3R,4R,6R)-4,6-Dimethyl-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]oxy-2,3-dihydroxycyclohexyl]-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride; U-10149A; Antibiotic U-10149A; Lincomycin B monohydrochloride
EINECS	Contact for details

Quality Control

Our Lincomycin B Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and potency meet high-grade standards suitable for research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for key parameters including assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.