Description

L-Proline, 1-Phenyl-5-Thioxo-, Methyl Ester (9Ci) is a specialized proline derivative featuring a phenylthioxo moiety. This compound is a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and industrial R&D departments focused on medicinal chemistry, peptide mimetics, and asymmetric catalysis. The product is supplied with a guaranteed CAS number of 146500-36-9 for precise identification and regulatory compliance.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other targeted therapies.
• Peptidomimetics Research: Used to construct constrained peptide analogs and non-natural amino acid derivatives to study protein-protein interactions and enhance metabolic stability.
• Asymmetric Synthesis Catalyst/ Ligand: Acts as a precursor for chiral ligands or organocatalysts used in enantioselective transformations.
• Agrochemical Research: Employed in the synthesis of novel, biologically active compounds for crop protection and pest management.
• Academic & Industrial R&D: A critical reagent for methodological studies in organic chemistry and for exploring new chemical spaces in drug discovery programs.
• Chemical Reference Standard: Used as a high-purity standard for analytical method development and quality control in related chemical processes.

Basic Information

Product Name	L-Proline, 1-Phenyl-5-Thioxo-, Methyl Ester (9Ci)
CAS No.	146500-36-9
Molecular Formula	C13H15NO2S
Molecular Weight	249.33 g/mol
Synonyms	Methyl (2S)-1-(phenylcarbamothioyl)pyrrolidine-2-carboxylate; L-Proline, 1-[(phenylamino)thioxomethyl]-, methyl ester; (2S)-1-[(Phenylcarbamothioyl)]-2-pyrrolidinecarboxylic acid methyl ester; Methyl L-prolinate, N-phenylthioxo derivative; 1-Phenyl-5-thioxo-L-proline methyl ester; CAS 146500-36-9
EINECS	Contact for details

Quality Control

Our L-Proline, 1-Phenyl-5-Thioxo-, Methyl Ester (9Ci) is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.