Description

1-n-Cbz-3-Pyrrolidinone is a versatile and high-purity chemical building block, specifically a protected pyrrolidinone derivative. This compound is critical for the synthesis of complex molecules, offering a reactive ketone group and a Cbz-protected amine for selective deprotection. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for constructing novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) agents, kinase inhibitors, and other bioactive heterocycles.
• Agrochemical Synthesis: Used in the creation of novel pesticides and herbicides, where the pyrrolidinone scaffold contributes to biological activity.
• Peptidomimetics & PROTACs: Serves as a crucial component in the design of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.
• Material Science Research: Employed as a monomer or precursor in the development of specialized polymers and functional materials.
• Academic & Contract Research: Essential for synthetic chemistry research in academic institutions and contract research organizations (CROs) exploring new organic methodologies.
• Custom Synthesis: A starting point for custom manufacturing services to produce specific, high-value derivatives not available off-the-shelf.

Basic Information

Product Name	1-n-Cbz-3-Pyrrolidinone
CAS No.	130312-02-6
Molecular Formula	C₁₃H₁₅NO₃
Molecular Weight	233.26 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-pyrrolidinone; 1-Carbobenzyloxy-3-pyrrolidinone; 1-Cbz-3-pyrrolidinone; 3-Oxo-1-pyrrolidinecarboxylic acid phenylmethyl ester; N-Carbobenzyloxy-3-pyrrolidinone; N-Cbz-3-pyrrolidinone; 1-(Phenylmethoxycarbonyl)pyrrolidin-3-one
EINECS	Contact for details

Quality Control

Our 1-n-Cbz-3-Pyrrolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.