Description

Glycocholic Acid, [Glycine-1-14C] is a radiolabeled derivative of the primary bile acid, glycocholic acid, where the glycine moiety is tagged with carbon-14 at the C-1 position. This compound is an essential tool for advanced metabolic and pharmacokinetic research, enabling precise tracking of bile acid transport, metabolism, and enterohepatic circulation. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and CROs (Contract Research Organizations) focused on hepatobiliary function, drug interaction studies, and the development of novel therapeutic agents.

Application

• Tracer Studies in Bile Acid Metabolism: Used to investigate the synthesis, conjugation, and enterohepatic recycling of bile acids in in vitro and in vivo models.
• Drug Disposition Research: Employed as a probe to study the potential inhibitory or inductive effects of new chemical entities on bile acid transporters (e.g., NTCP, ASBT).
• Pharmacokinetic (PK) and ADME Studies: Facilitates the quantitative analysis of absorption, distribution, metabolism, and excretion pathways for compounds affecting the hepatobiliary system.
• Biochemical Pathway Elucidation: Aids in mapping specific metabolic pathways and enzymatic transformations involving conjugated bile acids.
• Development of Diagnostic Assays: Serves as a critical standard or tracer in the development of radioimmunoassays (RIA) or other analytical methods for bile acid detection.

Basic Information

Product Name	Glycocholic Acid, [Glycine-1-14C]
CAS No.	52632-27-6
Molecular Formula	C₂₆H₄₂¹⁴CNO₆
Molecular Weight	~465.6 g/mol (exact mass depends on ¹⁴C enrichment)
Synonyms	N-[(3α,5β,7α,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]glycine-1-¹⁴C; Cholylglycine-1-¹⁴C; Glycocholate-1-¹⁴C; 3α,7α,12α-Trihydroxy-5β-cholan-24-oyl Glycine-1-¹⁴C; Taurocholic Acid Glycine-1-¹⁴C Analog; ¹⁴C-Glycocholic Acid; Radiolabeled Glycocholic Acid
EINECS	Contact for details

Quality Control

Every batch of Glycocholic Acid, [Glycine-1-14C] is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our quality control includes rigorous analytical testing via HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the specific activity (mCi/mmol or GBq/mmol), radiochemical purity, chemical purity, and solvent information. We adhere to GLP (Good Laboratory Practice) standards to support your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store the product at or below -20°C. The solution should be kept in the original solvent as specified on the label and COA. Allow the vial to reach room temperature before opening to minimize moisture condensation. Store in accordance with local regulations for radioactive materials.

Specification

Item	Specification
Appearance	Solution (color as per COA)
Identification (HPLC)	Conforms to reference standard
Specific Activity	50-60 mCi/mmol (1.85-2.22 GBq/mmol) (Typical)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Solvent	Ethanol:Water mixture (specified on COA)
Concentration	0.1 mCi/mL (3.7 MBq/mL) (Typical)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.