Description

6-Thio-3-Deazaguanine is a synthetic purine analog and a potent inhibitor of the enzyme guanase, which plays a crucial role in purine metabolism. This compound matters for its significant research utility in studying nucleotide metabolism, enzyme kinetics, and as a potential biochemical tool in oncology research. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on metabolic pathway analysis and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a specific inhibitor of guanase (guanine deaminase) to study purine salvage pathways and nucleotide metabolism in vitro.
• Oncology Research: Investigated as a potential tool compound for its effects on cellular proliferation and metabolism in cancer cell lines.
• Enzyme Kinetics Studies: Serves as a substrate analog in enzymatic assays to determine kinetic parameters and inhibition mechanisms.
• Metabolic Pathway Analysis: Aids in mapping and understanding purine interconversion and degradation routes in biological systems.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, or NMR for method development and quality control in research settings.
• Pharmaceutical Development: Potential intermediate or starting material in the synthesis of more complex nucleoside analogs for therapeutic evaluation.

Basic Information

Product Name	6-Thio-3-Deazaguanine
CAS No.	52605-85-3
Molecular Formula	C₆H₆N₄S
Molecular Weight	166.20 g/mol
Synonyms	6-Thio-3-deazaguanine; 6-Mercapto-3-deazaguanine; 2-Amino-6-mercapto-3H-imidazo[4,5-c]pyridin-4-one; 6-Thio-3-deazaguanosine precursor; TDG; Guanase inhibitor; 6-T-3-DG; 6-Thio-deazaguanine
EINECS	Contact for details

Quality Control

Our 6-Thio-3-Deazaguanine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.