Description

Aphidicolin Diacetate is a chemically modified derivative of the natural tetracyclic diterpenoid, aphidicolin, designed for enhanced stability and specific biological research applications. This compound is a critical tool for studying eukaryotic DNA replication, as it acts as a potent and specific inhibitor of DNA polymerase α and δ. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for investigating cell cycle mechanisms, antiviral strategies, and cancer biology.

Application

• Biochemical Research: A key reagent for studying the mechanisms of eukaryotic DNA replication and cell cycle progression.
• Antiviral Studies: Used in research to investigate the replication of DNA viruses, such as herpesviruses and poxviruses.
• Cancer Research: Employed to inhibit cell proliferation in studies focused on oncology and the development of chemotherapeutic agents.
• Cell Synchronization: Facilitates the synchronization of cultured cells at specific phases of the cell cycle for experimental analysis.
• Enzyme Inhibition Assays: Serves as a specific inhibitor in assays targeting DNA polymerase α and δ activity.
• Academic & Pharmaceutical R&D: Essential for basic biological research and drug discovery pipelines focused on replication targets.

Basic Information

Product Name	Aphidicolin Diacetate
CAS No.	52592-12-8
Molecular Formula	C₂₄H₃₄O₇
Molecular Weight	434.52 g/mol
Synonyms	Aphidicolin 17,18-Diacetate; NSC 234714; 3α,16β,17-Trihydroxy-4β-methyl-13(16→17)abeo-5α,8β,9β,10α,13α-podocarpa-6,11,13-trien-19-oic Acid γ-Lactone 17,18-Diacetate; Aphidicolin Diacetate (16α,17-Diacetate); (3R,4R,4aS,6aS,9S,11aR,11bS)-4,9-Bis(acetyloxy)-3,4,4a,6a,9,10,11,11a-octah-6,11b-methanocyclohepta[a]naphthalene-3,6a,10,11-tetrol 3,6a-Diacetate
EINECS	Contact for details

Quality Control

Our Aphidicolin Diacetate is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.